Key Features:

✅ Interactive Power Analysis - Real-time power curves and sample size calculations
✅ Adaptive Design Planning - O'Brien-Fleming alpha spending with futility/efficacy stopping rules
✅ Sample Size Re-estimation - Dynamic adjustment based on interim results
✅ Design Comparison - Side-by-side analysis of traditional vs. adaptive approaches
✅ Regulatory-Ready - Pre-specified adaptation rules and comprehensive documentation

🎯 Perfect for:

• Biostatisticians planning adaptive trials • Clinical researchers optimizing study efficiency
• Pharmaceutical teams reducing development timelines • Academic institutions teaching trial methodology

💡 Why This Matters:

Adaptive designs can reduce sample sizes by up to 30% while maintaining statistical rigor - crucial for faster drug development and reduced costs in clinical research.

The tool handles both one-sided and two-sided hypothesis testing, implements proper alpha spending functions, and provides clear visualizations to support regulatory submissions.

💡 House to Use:

Click the link below to open the Shiny app.

Then, adjust your parameters using the sliders and select the buttons you need.

https://kadiroo-jayaraman.shinyapps.io/adaptive-trial-designer/

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This educational tool is designed for planning purposes. All adaptive procedures should be pre-specified and reviewed by qualified biostatisticians before implementation.

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